<address id="j3vpn"></address>

    <noframes id="j3vpn">
    <form id="j3vpn"></form>
    <form id="j3vpn"><nobr id="j3vpn"><th id="j3vpn"></th></nobr></form>

    <form id="j3vpn"></form>

    <form id="j3vpn"></form>

    <noframes id="j3vpn"><form id="j3vpn"></form>

    <sub id="j3vpn"><listing id="j3vpn"><menuitem id="j3vpn"></menuitem></listing></sub>

    Service and cooperation

    IgG-like Bispecific Antibody Development

    We provide service to produce IgG-like bispecific antibody from two antibodies which are provided by customers

    Based on knobs into holes (KIH) technology for heavy chain heterodimerization, we have developed a method to facilitate correct pairing of cognate heavy and light chains. Our approach replaces the native interchain disulfide bond between the heavy and light chain in one Fab arm with an engineered interchain disulfide bond. The native interchain disulfide bond between the heavy and light chain in another Fab arm is not modified (wild-type). We have identified several different engineered interchain disulfide bonds, which can be chosen to use for the production of IgG-like bispecific antibody.

    Our approach can be used to efficiently produce an IgG-like bispecific antibody from two pre-existent antibodies (IgG1, IgG2, IgG3, IgG4, Kappa and Lambda light chains). This approach is easy to operate without using any artificial linkers and common light chains. The resulting IgG-like bispecific antibody is stable and amenable to commercial manufacturing.


      Contact us

      0571-89059592

      Email:info@genekine.com.cn

      Add:Room 1001, Unit 6, Building 6, No. 1500, Wenyi West Road, Yuhang District, Hangzhou City, Zhejiang Province

    Follow us

    Hangzhou Jingyinkang Biological Technology Co., Ltd. | 浙ICP備15033920號 | Technical Support:REVAN

    Hangzhou Jingyinkang Biological Technology Co., Ltd.

    Follow us

    Online
    Tel

    0571-89059592

    日本一卡精品视频免费